Coding

Part:BBa_K3244015

Designed by: Mohammad Tarek Mansour   Group: iGEM19_AFCM-Egypt   (2019-10-10)


IL-18

IL-18 cytokine for TRUCK CAR

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


MIT_MAHE 2020

Summary

Interleukin-18 (IL-18) is a member of IL-1 family of cytokines. It is synthesized as an inactive precursor which can be processed by caspase-1 to an active cytokine. The precursor is constitutively present in nearly all cells in healthy humans and animals. Its activity is balanced by the presence of a high affinity naturally occurring IL-18 binding protein. It plays a major role in production of interferon -γ from T-cells and natural killer cells. It is said to play a part in several autoimmune diseases, myocardial function, emphysema, metabolic syndromes, psoriasis, inflammatory bowel disease, hemophagocytic syndromes, macrophage activation syndrome, sepsis, and acute kidney injury. In humans, disease severity can be associated with an imbalance of IL-18 to IL-18BP such that the levels of free IL-18 are elevated in the circulation.

References

1. Dinarello, C. A., Novick, D., Kim, S., & Kaplanski, G. (2013). Interleukin-18 and IL-18 binding protein. Frontiers in immunology, 4, 289. https://doi.org/10.3389/fimmu.2013.00289

[edit]
Categories
//collections/immune_regulation/inflammatory
Parameters
None